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InnoCentive Challenges: Chemistry

Tuesday, 28 October 2008

Conversations-on-Innovations: Link: Limits to Nanoelectronics – Theoretical and Physical Limits-Plasmonics – Economic analogies of limits to growth fr

Conversations-on-Innovations: Link: Limits to Nanoelectronics – Theoretical and Physical Limits-Plasmonics – Economic analogies of limits to growth from the bulk metals industry

Wednesday, 8 October 2008

Conversations-on-Innovations: Forgotten Scientists? -"Should auld acquaintences be forgot and never brought to mind!"

Conversations-on-Innovations: Forgotten Scientists? -"Should auld acquaintences be forgot and never brought to mind!"

Nobel Chemistry 08 - Fluo Proteins - Biomarker -Dangerous and Chancey Business

Let me tell you this anecdote:

The 2008 Prize for chemistry brings to mind an Innocentive Challenge, to find a biomarker, for Charcot’s Disease – a still incurable type of sclerosis. This challenge, by the way, is still open to the end of the current year, from memory, and is now supported by the Rockefeller Foundation. I echoed this at the time; for the importance of the subject and the equivalent highest award of all Innocentive challenge rewards. In my humbler case it was essentially for marketing purposes-a good thing to do, to help in any small way. It was impossible for me to do more than help a foreign contribution via my english mother tongue. I really took “cold feet” when reading a case study in the ENBIS (European Network for Business and Industrial Statistics) pages of Scientific Computing World-Europa Science. The ENBIS Case concerned a biomarker for something, maybe Alzeimer, something serious in any case. To an innocent novice, such as I, I felt that a biomarker would be less dangerous than a the drug itself. Well, injected into a wee rat - the rat “kicked the bucket” ie died. Injected into our close cousin the pig – it got an unpleasant skin rash, so it was said. Result? This biomarker was abandoned for any human trials.

Funny how the mind can be stimulated by taking any small step forward. This anecdote is just to give the news reader some idea just how serious, difficult and often ungrateful, biomedical-biochemistry can be.

The prestigious 10 million Swedish crown ($1.4 million) prize recognized Osamu Shimomura of Japan and Americans Martin Chalfie and Roger Tsien for their discovery of the protein GFP. The the Nobel Committee for Chemistry at the Royal Swedish Academy of Sciences' statement said:
"The remarkable brightly glowing green fluorescent protein, GFP, was first observed in the beautiful jellyfish, Aequorea victoria in 1962,".

"Since then, this protein has become one of the most important tools used in contemporary bioscience. With the aid of GFP, researchers have developed ways to watch processes that were previously invisible, such as the development of nerve cells in the brain or how cancer cells spread."

Chalfie picked up on the discovery to demonstrate the value of GFP as a genetic tag for biological phenomena and Tsien extended the color palette beyond green, allowing scientists to follow several different biological processes at the same time.

SCIENCE (certainly) AND ART?

The strong green color of the jellyfish protein appears under blue and ultraviolet light, allowing researchers to illuminate cancer tumors, show the development of Alzheimer's disease in the brain or the growth of harmful bacteria. GFP has been used for art as well as for science. A green-glowing bunny named Alba was made in 2000 at the request of Chicago artist Eduardo Kac and green-glowing pigs have been gene engineered and bred to make green-glowing piglets!

Incredible cf. Anecdote above. Reminds me also of Dolly the sheep, 1st known sucessive clone.

Other Posts on Nobel Prizes 2008

Sources
-Yahoo News By Niklas Pollard (Editing by Angus MacSwan)
-Innocentive. ENBIS.
-SCW - Scientific Computing World - Europa Science.

NOBEL PRIZE AWARDS -2008 Fathers of Invention II -

Biochemistry and Nanotechnology are two areas tipped for the Nobel Prize in Chemistry.

The Nobel prize Winners, the elected few in the heady rarefied atmosphere of the highest summits of scientific endeavour reached and the national flag firmly planted. The "Nobel Class" all surely highly eminent, deserving candidates. "Losers?" often applied undeservedly in the world of sport etc (note the order - not "the sporting world-or sports world") The word "looser is obviously hardly applicable. I logged a post in my "conversations" blog_link html on the "human angle" with one recent and currently open wound example-in the medical field. A day latter I had news that a support committee will be formed to tell as best as possible the full story to this great research break-through. Great, all have certainly made remarkable contributions.

Better I hope to improve my own approach to honouring science. In fact an excellent way is to have the full list of candidates and their main contribution - the detail will drown the ordinary even the most highly educated reader.

Here is one prognostic "Biochem. or Nanotech-em"? -Other?:

If the vote sway in favour of Biochemistry, Americans Stuart Schreiber and Gerald Crabtree are among potential candidates for pioneering work in chemical biology, shedding light on how tiny molecules can be used on cell circuits and signaling pathways.

On the other hand if the prize honours nanotechnology, sways towards the European continent, possible winners could include British (Scottish) chemist James Fraser Stoddart or again to Asia-Pacific, Japan's Sumio Iijima, who discovered carbon nanotubes in 1991. who needs no introduction to the materials chemistry and materials science, technology & engineering communities.

Good luck all whatever the outcome.

Comments welcome, "No-Holds-Bard".


Source:

Yahoo News

Wikipedia: James Fraser Stoddart

Wikipedia: Stuart Schreiber and Gerald Crabtree

Wikipedia Sumio Iijima

Tuesday, 7 October 2008

NOBEL PRIZE AWARDS -2008 "Poetry to the Ears & Father of Invention"

Calling all Scientists! "Check and grab the Nobel Prize Widget for your blogs, websites and enjoy the lates Nobel news.

ref: Nobel Prize Organisation